Z. Jia

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Small molecule NS11021 promotes BK channel activation by increasing inner pore hydration

This paper investigates how the small molecule NS11021 activates BK channels by increasing inner pore hydration through atomistic simulations.

α-Aminooxyacetic acid derivatives acting as pro-drugs against Mycobacterium tuberculosis

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

Engineering oncogenic hotspot mutations on SF3B1 via CRISPR-directed PRECIS mutagenesis

This paper develops PRECIS, a method combining prime editing and a synthetic intron reporter to efficiently generate SF3B1 mutant cell lines that recapitulate cancer-related splicing and CNV events.

Thiolation-Based Protein-Protein Hydrogels for Improved Wound Healing

This paper develops protein-protein hydrogels using thiolation and Ag-S bonding to enhance wound healing properties in both diabetic and UV-burn models.

Genetically Encodable in situ Gelation Redox-Responsive Collagen-Like Protein Hydrogel for Accelerating Diabetic Wound Healing

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

Ionic polyphosphorylation of histidine repeat proteins by inorganic polyphosphate

The paper identifies 30 human and yeast histidine repeat proteins modified by inorganic polyphosphate, showing this modification disrupts phase separation and inhibits kinase and transcription factor activity.

Integrating EM and Patch-seq data: Synaptic connectivity and target specificity of predicted Sst transcriptomic types

The paper predicts MET-type identities from EM data and shows they have distinct connectivity patterns and synapse targets.

Microbial diversity and community dynamics in an active, high CO2 subsurface rift ecosystem

The paper investigates microbial diversity and community dynamics in the Eger Rift subsurface, revealing a diverse archaeal population and evidence of anaerobic and acidophilic communities.

ACSF2: A MEDIUM-CHAIN ACYL-CoA SYNTHETASE WITH A POTENTIAL ROLE IN NEURONAL DIFFERENTIATION

This paper characterizes ACSF2, a medium-chain acyl-CoA synthetase, showing its role in neuronal differentiation through localization, enzymatic activity, and functional impact on neurite outgrowth.

An allosteric agonist activates BK channels by perturbing coupling between Ca2+ binding and pore opening

The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules

This paper introduces a bioorthogonal surface functionalization method using tetrazine ligation to graft bioactive molecules, demonstrating improved cytocompatibility and antimicrobial properties.

Genomics-informed insights into microbial degradation of N,N-dimethylformamide

This study identifies genomic diversity and degradation pathways for N,N-dimethylformamide (DMF) by analyzing 20,762 genomes, revealing plasmid-mediated degradation and anaerobic potential for methane production.

Specific PIP2 Binding Promotes Calcium Activation of TMEM16A Chloride Channels

This study identifies that specific PIP2 binding to TMEM16A promotes calcium activation by enabling spontaneous opening of the permeation pathway in the Ca2+-bound state.

The jasmine (Jasminum sambac) genome and flower fragrances

This study presents the first de novo genome of Jasminum sambac and identifies gene clusters and pathways involved in flower fragrance biosynthesis.

Integrative Transcriptomic Analysis Reveals the Immune Mechanism for A CyHV-3-Resistant Common Carp Strain

This study identifies immune mechanisms underlying CyHV-3 resistance in a common carp strain through transcriptomic analysis of gene and lncRNA expression.

Resuscitation of soil microbiota after > 70-years of desiccation

This study assesses bacterial abundance and diversity in 70-year-old desiccated soils, showing significant resuscitation potential and activity of certain taxa after rewetting.

Structural insight into outer membrane asymmetry maintenance of Gram-negative bacteria by the phospholipid transporter MlaFEDB

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

Nonspecific membrane interactions can modulate BK channel activation

This study shows that the C-linker in BK channels modulates activation through nonspecific membrane interactions, challenging previous assumptions about its role.

The dark side of amyloid aggregation: Exploring the productive and non-productive pathways with multi-scale modeling

This paper develops a multi-scale modeling approach to study amyloid fibril growth kinetics and mutation effects using Markov State Models derived from molecular dynamics simulations.

New mechanism-based inhibitors of aspartate transcarbamoylase for anticancer drug development

This study identifies new ATCase inhibitors by targeting a previously unknown regulatory region and active site, showing strong anticancer effects in cell lines and xenograft models.

Assessment of gibberellin (GA4+7) mediated changes on grain filling, hormonal behaviour and antioxidants in high-density maize (Zea Mays L.)

This study evaluates the effects of GA4+7 application on maize grain filling, hormone levels, and antioxidants under different treatment methods, finding that 60 mg L-1 GA4+7 improves grain filling and delays leaf senescence.

Structure-guided disruption of pseudopilus tip inhibits Type II secretion in Pseudomonas aeruginosa

The paper identifies XcpV and XcpW as essential pseudopilin components of the T2SS tip, develops structure-based inhibitory peptides that disrupt the complex and inhibit T2SS in vivo, reducing P. aeruginosa virulence.