SPARC regulation of PMN clearance protects from pristane induced lupus and rheumatoid arthritis
S. Sangaletti, L. Botti, A. Gulino, D. Lecis, B. Bassani, P. Portararo, M. Milani, L. De Cecco, M. Dugo, C. Tripodo, M. P. Colombo
This study shows that SPARC deficiency leads to increased PMN clearance failure, promoting autoimmunity in lupus and arthritis models.
bioRxiv · Aug 10, 2020Immunology