M. Milani

BAX and BAK expression triggers multiple IRE1 signaling outputs under ER stress

This study shows that BAX and BAK deficiency increases ER stress threshold for XBP1 splicing and reduces RIDD substrate degradation and IRE1 phosphorylation.

NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates

This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.

Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia

This study shows that frataxin deficiency in microglia shifts metabolism to glucose catabolism, causing inflammation, which is mitigated by butyrate treatment.

The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis

This study shows that IRE1 regulates collagen secretion via P4HB, contributing to liver fibrosis in models of CCl4 and high fat diet.

Combined in silico docking and in vitro antiviral testing for drug repurposing identified lurasidone and elbasvir as SARS-CoV-2 and HCoV-OC43 inhibitors

The paper identifies lurasidone and elbasidone as inhibitors of SARS-CoV-2 and HCoV-OC43 through in silico docking and in vitro testing.

SPARC regulation of PMN clearance protects from pristane induced lupus and rheumatoid arthritis

This study shows that SPARC deficiency leads to increased PMN clearance failure, promoting autoimmunity in lupus and arthritis models.