D. Chaussabel

IL-3-driven T cell-basophil crosstalk enhances anti-tumor immunity

This study shows that IL-3 enhances anti-tumor immunity by promoting CTL-basophil interactions, improving CTL activity and tumor suppression.

Biological modifications of the immune response to COVID-19 vaccine in patients treated with rituximab and immune-checkpoint inhibitors

This study examines how rituximab and immune-checkpoint inhibitors affect immune responses to a COVID-19 booster vaccine, finding rituximab impairs interferon response and ICI maintains normal immune profiles.

Protocol for primary human lung organoid-derived air-liquid interface in vitro model to study response to SARS-CoV-2

This paper presents a protocol for creating human lung organoid-derived air-liquid interface cultures to study SARS-CoV-2 infection and includes quality control and monitoring methods.

Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia

This study examines the spatiotemporal immune response to SARS-CoV-2 in human broncho-alveolar epithelia, finding variant-specific kinetics and spatially organized gene expression patterns.

At-home blood collection and stabilization in high temperature climates using homeRNA

This study evaluates the performance of homeRNA, a home-based blood collection and RNA stabilization system, in high-temperature environments, showing acceptable RNA integrity in pilot studies in Qatar and the USA.

High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infection

This study uses high-temporal-resolution transcriptome profiling to compare interferon responses after mRNA vaccination and SARS-CoV-2 infection, identifying distinct signatures linked to immune outcomes.

A modular framework for the development of targeted Covid-19 blood transcript profiling panels

The paper develops a modular framework for designing targeted blood transcript profiling panels to study the immune response to SARS-CoV-2 infection.

Identification of erythroid cell positive blood transcriptome phenotypes associated with severe respiratory syncytial virus infection

The paper identifies erythroid cell-associated blood transcriptome phenotypes linked to severe RSV infection using meta-analysis of public datasets.

Pazopanib induces dramatic but transient contraction of myeloid suppression compartment in favor of adaptive immunity

This study shows pazopanib reduces myeloid suppression and boosts adaptive immunity in mRCC patients, with effects peaking at 3 months.

Development and Characterization of a Fixed Repertoire of Blood Transcriptome Modules Based on Co-expression Patterns Across Immunological States

The paper develops a fixed repertoire of blood transcriptome modules based on co-expression patterns across immunological states to provide a stable framework for analyzing and interpreting blood transcriptome data.

A neutrophil-driven inflammatory signature characterizes the blood cell transcriptome fingerprints of Psoriasis and Kawasaki Disease

The paper compares blood transcriptome signatures of psoriasis and Kawasaki Disease, identifying a shared neutrophil-driven inflammatory signature.

A Transcriptome Fingerprinting Assay for Clinical Immune Monitoring

The paper develops a targeted transcriptome fingerprinting assay using modular transcriptional repertoires to assess immune functions in clinical settings.

Characterization of Peripheral Blood Mononuclear Cells Gene Expression Profiles of Pediatric Staphylococcus aureus Persistent and Non-Carriers Using a Targeted Assay

The paper compares gene expression profiles of PBMCs from pediatric S. aureus carriers and non-carriers using a targeted assay, finding distinct innate immune responses to live vs. dead bacteria.

A curated transcriptome dataset collection to investigate inborn errors of immunity.

The paper compiles a curated transcriptome dataset collection from PID patients and controls to enable meta-analysis and improve understanding of inborn errors of immunity.

Elevation of FAM129A in neutrophils exposed to serum of patients with severe sepsis: in silico investigations during a hands on training workshop and follow on validation of protein expression in neutrophils

The paper investigates FAM129A expression in neutrophils exposed to sepsis serum using transcriptome data and confirms surface expression through bench validation.

A curated collection of transcriptome datasets to investigate the molecular mechanisms of immunoglobulin E-mediated atopic diseases

The paper curates 30 transcriptomic datasets from GEO to study IgE-mediated atopic diseases and provides an online tool for data visualization and metadata annotation.

The abundance of Nudix hydrolase 16 transcripts is elevated in human sepsis: perspectives gained during a hands-on reductionist investigation workshop.

The paper investigates NUDT16 transcript abundance in sepsis using omics data and public datasets, finding elevated levels in septic patients compared to controls.

IRF4 haploinsufficiency in a family with Whipples disease

This study identifies IRF4 haploinsufficiency as the genetic cause of Whipples disease in a family, showing age-dependent incomplete penetrance and chronic Tw carriage preceding disease onset.