ImmunologybioRxiv
The macrophage reprogramming ability of antifolates reveals soluble CD14 as a potential biomarker for methotrexate response in rheumatoid arthritis
S. Fuentelsaz-Romero, C. Barrio Alonso, R. Garcia Campos…·A. Puig-Kröger
This study shows that antifolates reprogram macrophages via one-carbon metabolism, revealing soluble CD14 as a biomarker for methotrexate response in rheumatoid arthritis.
DOI 10.3389/fimmu.2021.776879