Distinct bile salt hydrolase substrate preferences dictate C. difficile pathogenesis
M. H. Foley, M. E. Walker, A. K. Stewart, S. O'Flaherty, E. C. Gentry, G. Allen, S. Patel, M. Pan, V. V. Beaty, M. E. Vanhoy, M. K. Dougherty, S. K. McGill, A. Gulati, P. Dorrestein, E. S. Baker, , C. M. Theriot
The paper identifies bile salt hydrolase (BSH) substrate preferences and shows they inhibit C. difficile by altering bile acid pools in CDI models.
bioRxiv · Mar 24, 2022 · PreprintMicrobiology