C. M. Theriot

This study identifies microbial DNA and protein in casein-based diets, showing they contribute to microbiome measurements and are absent in other protein sources.

This study investigates how Bacteroides thetaiotaomicron's bile acid altering enzymes affect its fitness and metabolic transcriptome under bile acid exposure.

This study shows that bile acid epimers iLCA and iaLCA inhibit C. difficile growth and toxin activity while sparing gut commensals.

This study shows that taurine-conjugated ursodeoxycholic acid (TUDCA) inhibits C. difficile toxin-induced apoptosis in Caco-2 cells, while unconjugated UDCA does not, highlighting the importance of bile acid conjugation in CDI therapy.

The paper identifies bile salt hydrolase (BSH) substrate preferences and shows they inhibit C. difficile by altering bile acid pools in CDI models.

This study investigates how trans-4-hydroxyproline affects the metabolism of C. difficile and commensal Clostridia, revealing differential gene expression and microbiota changes in mice.

This study shows C. difficile uses toxin-induced inflammation to alter host nutrient availability and outcompete Bacteroides by utilizing collagen-derived amino acids.

This paper shows that UDCA reduces inflammation during CDI by altering bile acids and modulating NF-κB signaling through FXR and TGR5 receptors.

This study shows that commensal Clostridia with the bai operon inhibit C. difficile growth in a strain-dependent manner through bile acid conversion, but C. difficile outcompetes them in co-culture.

This study identifies C. difficile strains in companion animals and their impact on host fecal microbiota, showing potential zoonotic transmission and shared ribotypes with human infections.

This study shows that ursodiol administration in mice causes weight loss and changes in gut microbiota and bile acid pools.

This study examines microbiota and metabolome recovery in patients with recurrent CDI after FMT, identifying microbial associations with metabolite changes and individualized recovery patterns.