Lipophilic compounds restore wt function of neurodevelopmental-associated KCNQ3 mutations.
M. A. Edmond, A. Hinojo-Perez, M. Efrem, Y.-C. Lin, I. Shams, S. Hayoz, A. de la Cruz, M. E. P. rodriguez, M. Diaz-Solares, D. M. Dykxhoorn, Y. Luo, R. B. Soria
The paper investigates how two KCNQ3 mutations impair channel function and shows that polyunsaturated fatty acids can restore wild-type function in these mutations.
bioRxiv · Mar 13, 2024 · PreprintBiophysics