Y.-C. Lin

StomaVision: stomatal trait analysis through deep learning

StomaVision automates stomatal trait analysis from micrographs, revealing physiological responses to heat stress across plant species.

The L-lactate dehydrogenases of Pseudomonas aeruginosa are conditionally regulated but both contribute to survival during macrophage infection

This paper investigates the regulation and role of L-lactate dehydrogenases LldD and LldA in Pseudomonas aeruginosa, showing they are conditionally expressed and contribute to survival during macrophage infection.

Lipophilic compounds restore wt function of neurodevelopmental-associated KCNQ3 mutations.

The paper investigates how two KCNQ3 mutations impair channel function and shows that polyunsaturated fatty acids can restore wild-type function in these mutations.

Cross-institutional HER2 assessment via a computer-aided system using federated learning and stain composition augmentation

This paper develops a HER2 assessment system using federated learning and stain composition augmentation, achieving over 90% accuracy across two institutions with improved generalizability.

Microscopy-guided subcellular proteomic discovery by high-speed ultra-content photo-biotinylation

This paper introduces a microscopy-guided proteomics method called optoproteomics to identify subcellular proteins with high spatial precision and sensitivity.

Binding Free Energies of Piezo1 Channel Agonists at Protein-Membrane Interface

This study computes binding free energies of Yoda1 and its analogs at Piezo1 channels using molecular dynamics to predict agonist/inhibitor effects and guide drug design.

Anti-spike antibody response to natural infection with SARS-CoV-2 and its activity against emerging variants

This study examines spike-specific antibody responses in SARS-CoV-2 natural infections, showing waning immunity over 11 months and reduced activity against emerging variants like Beta and Omicron.

Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).

This paper develops a novel peptide aptamer that binds eIF4E's cap-binding site using PELE, showing nanomolar affinity and intracellular function modulation.

The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion

This study examines beta thalassaemia heterozygous erythrocytes' properties and their effect on Plasmodium falciparum invasion, finding no overall reduction in invasion efficiency.

Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy

This study modifies lattice lightsheet microscopy to enable optogenetic manipulation of cell migration with high spatiotemporal resolution, achieving subcellular control and long-term cell viability.

Unifying Single-Channel Permeability from Rare-Event Sampling and Steady-State Flux

The paper compares three methods for computing ion channel permeability using molecular dynamics simulations and finds they yield consistent results.

DNA-free CRISPR-Cas9 gene editing of tetraploid tomatoes using protoplast regeneration

DNA-free CRISPR-Cas9 editing in wild tomatoes generates stable, inheritable diploid and tetraploid regenerants without chromosomal changes or off-target effects.

Precise control of microtubule disassembly in living cells

This study uses chemogenetics and optogenetics to precisely disassemble specific microtubule subtypes in living cells, revealing their roles in cellular processes.

Phosphatidylglycerol synthesis facilitates plastid gene expression and light induction of nuclear photosynthetic genes

This study investigates how phosphatidylglycerol (PG) deficiency affects gene expression and plant growth in Arabidopsis, showing its role in nuclear-encoded photosynthesis genes and chloroplast development.

Isolation, omics characterization and organotypic culture of alveolar type II pulmonary epithelial cells

This study isolates and characterizes alveolar type II cells using multi-omics and establishes a method for their organotypic culture.

Dependable Algorithm for Visualizing Snoring Duration through Acoustic Analysis

The paper develops an algorithm to visualize snoring duration through acoustic analysis, showing higher reproducibility with digital recordings than a smartphone app.

Synthetic dysmobility screen unveils an integrated STK40-YAP-MAPK system driving cell migration

The paper identifies an integrated STK40-YAP-MAPK system that regulates cell migration and introduces synthetic dysmobility as a strategy to disrupt migration by blocking collaborative pathways.

A Piezo1 open state reveals a multi-fenestrated ion permeation pathway

The paper uses molecular dynamics simulations to study Piezo1 channel opening and identifies a multi-fenestrated ion permeation pathway.

Free energy and kinetics of cAMP permeation through connexin26 hemichannel with and without voltage

This study investigates the free energy and kinetics of cAMP permeation through connexin26 hemichannels using simulations, revealing binding sites, directional transition rates, and the role of voltage and ions.

Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

This paper identifies Wnt signaling's role in mitosis by recruiting KIF2A to the spindle, ensuring chromosome congression and alignment in somatic and pluripotent cells.

Genomic, geographic and temporal distributions of SARS-CoV-2 mutations

This study analyzes the genomic, geographic, and temporal distribution of SARS-CoV-2 mutations using 1,932 genomes, identifying six phylogenetic clusters and a positive correlation between mutation count and case fatality.

Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence

This study shows Pseudomonas aeruginosa PA14 produces R-bodies, which are involved in virulence against nematodes through ribosome cleavage and translational inhibition.

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

Developmentally regulated activation of defense allows for rapid inhibition of infectionin age-related resistance to Phytophthora capsici in cucumber fruit

The paper investigates age-related resistance to Phytophthora capsici in cucumber fruit, identifying early transcriptional and biochemical changes that enable rapid pathogen inhibition.

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

Traction Force Microscopy by Deep Learning

This paper introduces a deep learning approach for traction force microscopy, achieving higher accuracy and resolution than conventional methods.

PIP3 depletion rescues myoblast fusion defects in human rhabdomyosarcoma cells

This study shows that PIP3 depletion via PTEN rescues myoblast fusion defects in human rhabdomyosarcoma cells by reducing bubbling blebs during differentiation.

Relationship between maximal incremental and high-intensity interval exercise performance in elite athletes

This study examines factors determining high-intensity interval training (HIIT) performance in athletes, finding that Blim is influenced by oxygen consumption, heart rate, and muscle oxygenation recovery rather than maximal VO2.

Clathrin’s adaptor interaction sites are repurposed to stabilize microtubules during mitosis

This paper identifies a novel role of clathrin in stabilizing microtubules during mitosis by repurposing its adaptor interaction sites to recruit GTSE1, which inhibits MCAK and supports chromosome congression.

Altering microtubule dynamics is synergistically toxic with inhibition of the spindle checkpoint

The paper identifies synergistic toxicity between microtubule dynamics alteration and SAC inhibition in aneuploid cells.