Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway
K. M. Hannan, P. Soo, M. S. Wong, J. K. Lee, N. Hein, M. Evers, K. D. Wysoke, T. D. Williams, C. Montellese, L. Smith, S. J. Al-Obaidi, L. Nunez-Villacis, P. Poh, M. Pavy, J.-S. He, , A. J. George
This study identifies the nucleolar surveillance pathway (NSP) as a central regulator of p53 stability, showing its role in integrating various cellular stresses and its potential as a therapeutic target in cancer.
bioRxiv · Jan 21, 2021 · PreprintCell Biology