The human RNA polymerase I structure reveals an HMG-like transcription factor docking domain specific to metazoans
J. L. Daiss, M. Pilsl, K. Straub, A. Bleckmann, M. Höcherl, F. B. Heiss, G. Abascal-Palacios, E. Ramsay, K. Tluckova, J.-C. Mars, A. Bruckmann, C. Bernecky, V. Lamour, K. Panov, A. Vannini, , C. Engel
The paper determines the structure of human RNA polymerase I, identifies a novel HMG-like domain in RPA1, and shows its role in recruiting Topoisomerase 2a and UBF for transcription regulation.
bioRxiv · Dec 22, 2021 · PreprintBiochemistry