L. Smith

Phylogenomics of the North American Desert Radiation Linanthus (Polemoniaceae) Reveals Mixed Trait Lability and No Single Geographic Mode of Speciation

This study uses genomic data to reconstruct the evolutionary history of Linanthus species, revealing complex speciation patterns and trait evolution in arid environments.

A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone

This study evaluates combinations of PDAC biomarkers across multiple labs, finding improved sensitivity and specificity for early-stage detection compared to CA19-9 alone.

Sex Differences and Role of Lysyl Oxidase Like 2 (LOXL2) in Angiotensin II-Induced Hypertension in Mice

This study investigates sex differences and the role of LOXL2 in Ang II-induced hypertension, finding that LOXL2 depletion protects males but worsens female aortic contractility.

Evaluation of the cross reactivity of neutralising antibody response in vaccinated human and convalescent hamster sera against SARS-CoV-2 variants up to and including JN.1 using an authentic virus neutralisation assay

This study evaluates neutralising antibody responses in vaccinated humans and convalescent hamsters against SARS-CoV-2 variants up to JN.1 using an authentic virus neutralisation assay, finding increased resistance to JN.1 in vaccinated individuals and specific neutralisation patterns in hamsters.

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

This study develops a trivalent RBD nanoparticle vaccine that protects mice against both merbecovirus and sarbecovirus challenges, including SARS-CoV, MERS-CoV, and SARS-CoV-2.

Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport

This study shows CLDN2 upregulation during pancreatitis limits disease progression by enhancing tight junction-controlled fluid transport in pancreatic ductal epithelium.

Unlocking Predictive Power: A Machine Learning Tool Derived from In-Depth Analysis to Forecast the Impact of Missense Variants in Human Filamin C

The paper develops a machine learning model to predict the impact of missense variants in human filamin C, achieving high accuracy in distinguishing pathogenic from non-pathogenic variants.

Development of a PNGase Rc column for online deglycosylation of complex glycoproteins during HDX-MS

The paper develops a PNGase Rc column for online deglycosylation during HDX-MS, enabling efficient analysis of glycoproteins and mapping of mAb binding epitopes.

Seafloor Incubation Experiments at Deep-Sea Hydrothermal Vents Reveal Distinct Biogeographic Signatures of Autotrophic Communities

The paper investigates microbial communities in hydrothermal vent discharge, finding geographic influences on community structure despite similar environmental conditions.

Optimization of universal primer set for the identification of all Influenza A viruses using real-time PCR

This study optimizes primer sets for detecting Influenza A viruses using RRT-PCR, finding that HA primers are most sensitive for field sample detection.

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

The paper identifies 14q32 cluster miRNAs as key regulators of transcriptional differences between IGHV-mutated and unmutated CLL, with miR-409-3p and miR-411-3p repressing GAB1.

A method for high throughput image based antifungal screening

This paper introduces a high-throughput image-based method for antifungal screening that improves upon traditional broth dilution protocols by incorporating time-resolved imaging to assess fungal growth and susceptibility quickly and accurately.

The hepatocyte insulin receptor is required to program rhythmic gene expression and the liver clock

This study investigates the role of the hepatocyte insulin receptor in regulating circadian gene expression and liver clock function in adult mice.

Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway

This study identifies the nucleolar surveillance pathway (NSP) as a central regulator of p53 stability, showing its role in integrating various cellular stresses and its potential as a therapeutic target in cancer.

Rapid GMP-compliant expansion of SARS-CoV-2-specific T cells from convalescent donors for use as an allogeneic cell therapy for COVID-19

The paper isolates and rapidly expands SARS-CoV-2-specific CD4+ and CD8+ T cells from convalescent donors under GMP standards, maintaining a central memory phenotype for therapeutic use in COVID-19.

A commercial autogenous injection vaccine protects ballan wrasse (Labrus bergylta, Ascanius) against Aeromonas salmonicida vapA type V

This study tests a commercial autogenous vaccine for ballan wrasse against Aeromonas salmonicida vapA type V, showing high protection and immune response.

Suramin potently inhibits binding of the mammalian high mobility group protein AT-hook 2 to DNA

This study identifies suramin as a potent inhibitor of HMGA2-DNA binding, showing it disrupts HMGA2 function and induces differentiation of brain tumor stem cells.

A photostable monomeric superfolder GFP

This paper describes msGFP2, a photostable monomeric superfolder GFP variant that retains superfolder properties while being as photostable as EGFP.

Occidiofungin, an actin binding antifungal with in vivo efficacy in a vulvovaginal candidiasis infection

This paper identifies occidiofungin, a novel antifungal compound produced by Burkholderia contaminans, which targets actin and shows efficacy in treating vulvovaginal candidiasis in mice with reduced host toxicity.