Auranofin Inhibition of Thioredoxin Reductase Sensitizes Lung Neuroendocrine Tumor Cells (NETs) and Small Cell Lung Cancer (SCLC) Cells to Sorafenib as well as Inhibiting SCLC Xenograft Growth
S. S. Johnson, D. Liu, J. T. Ewald, C. Robles-Planells, K. A. Christiansen, K. Bayanbold, B. R. Wels, S. R. Solst, M. S. ODorisio, B. G. Allen, Y. Menda, D. R. Spitz, M. Fath
This study shows auranofin inhibits TrxR in SCLC and NET cells, sensitizes them to sorafenib, and extends survival in xenograft models without toxicity.
bioRxiv · May 7, 2023Cancer Biology