Molecular basis of DNA recognition by the HMG-box-C1 module of Capicua
J. Webb, A. D. Gnann, J. J. M. Liew, M. Patterson, S. Paul, M. Fores, G. Jimenez, A. Veraksa, D. P. Dowling
This study determines the crystal structure of the CIC HMG-box and C1 domains bound to DNA, revealing their cooperative role in DNA recognition and how mutations disrupt this mechanism.
bioRxiv · Mar 28, 2022Biochemistry