BiochemistrybioRxiv
Molecular basis of DNA recognition by the HMG-box-C1 module of Capicua
J. Webb, A. D. Gnann, J. J. M. Liew…·D. P. Dowling
This study determines the crystal structure of the CIC HMG-box and C1 domains bound to DNA, revealing their cooperative role in DNA recognition and how mutations disrupt this mechanism.
DOI 10.1016/j.str.2025.08.018