S. Paul

Electrochemical cofactor recycling of bacterial microcompartments

The paper identifies a new function of an enzyme in bacterial microcompartments, proposing NAD+ regeneration and a role for the shell in redox separation.

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging

This paper introduces a microfluidics-based thrombus profiling assay that detects intensified biomechanical thrombogenesis in hypertension and aging, revealing a GPIb-integrin mechanosensing axis hyperactivity mechanism.

G-Quadruplex Mediated c-myc Specific Downregulation: A Unique Pathway of the Anticancer Action of Immunomodulator Drugs

This study shows that HCQ and CQ downregulate c-myc oncogene transcription via G4 stabilization, reducing tumor growth and enhancing chemotherapy in breast cancer models.

Conformational switching of Arp5 subunit differentially regulates INO80 chromatin remodeling

This study identifies two distinct binding mechanisms of the Arp5 subunit in the INO80 chromatin remodeler, showing their differential roles in nucleosome positioning and dimer exchange.

Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

This study investigates molecular glues targeting the ER/14-3-3 PPI to overcome endocrine resistance in breast cancer, showing suppression of ER activity and cell proliferation.

Transcriptome-wide mRNP condensation precedes stress granuleformation and excludes new mRNAs

The paper shows that mRNAs condense broadly in yeast under stress, independent of length, and new transcripts escape this condensation for selective translation.

Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency

The paper investigates RNA localization to nuclear speckles and finds that splicing efficiency is linked to transcript enrichment in these organelles.

A fungal metabolic regulator underlies infectious synergism during Candida albicans-Staphylococcus aureus intra-abdominal co-infection

This study identifies ZCF13 in Candida albicans as a regulator of ribose metabolism that enhances synergistic virulence with Staphylococcus aureus during intra-abdominal infection.

Delineating the shape of COPII coated membrane bud

The paper uses simulations to show that Sec23 and Sec24 act as spacers to determine the shape of COPII-coated membrane buds by dispersing Sar1 protomers.

Lipidomics of homeoviscous adaptation to low temperatures in Staphylococcus aureus utilizing exogenous straight-chain unsaturated fatty acids over biosynthesized endogenous branched-chain fatty acids

This paper shows that Staphylococcus aureus uses exogenous unsaturated fatty acids to enhance growth at low temperatures through lipid remodeling and carotenoid production.

Translational T-box riboswitches bind tRNA by modulating conformational flexibility

This study uses single-molecule FRET to analyze the binding mechanism of the Mycobacterium tuberculosis IleS T-box riboswitch, revealing a two-step model and the role of specific sequences in conformational flexibility and tRNA recognition.

The molecular basis for the increased stability of the FUS-LC fibril at the anionic membrane- and air-water interfaces

This study investigates how anionic membranes and air-water interfaces affect the stability of FUS-LC fibrils, showing increased stability at these interfaces.

Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

A SMG1 inhibitor disrupts nonsense-mediated decay, increasing expression of neoantigens from truncating mutations and enhancing immune targetable peptides on cancer cells.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Multiomic single-cell analysis identifies von Willebrand factor and TIM3-expressing BCR-ABL1+ CML stem cells

This study identifies VWF and TIM3-expressing BCR-ABL1+ CML stem cells using multiomic single-cell analysis, suggesting they are targets for sustained LSC elimination.

The Drosophila Tumour Suppressor Lgl and Vap33 activate the Hippo pathway by a dual mechanism, involving RtGEF/Git/Arf79F and inhibition of the V-ATPase.

This study shows Lgl activates the Hippo pathway via Vap33 through two mechanisms: interacting with RtGEF/Git/Arf79F and inhibiting V-ATPase activity.

Uracil-DNA Glycosylase of Murine Gammaherpesvirus 68 Binds Cognate Viral Replication Factors Independently of its Catalytic Residues

This paper identifies a non-enzymatic role for murine gammaherpesvirus 68 vUNG in forming a complex with viral DNA replication factors, independent of its catalytic activity.

Functional connectivity in northern swamp deer (Rucervus duvaucelii duvaucelii) population across a fragmented, human-dominated landscape along Gangetic Plains of north India: Implications for conservation in non-protected areas

The paper assesses genetic connectivity and dispersal patterns of northern swamp deer in a human-dominated landscape, finding two genetic lineages with low inbreeding and identifying conservation priorities.

Characterization of uranyl ion binding to amyloid beta (Aβ) peptides: effects on Aβ structure and aggregation

This study investigates how uranyl ions bind to amyloid beta peptides, altering their structure and aggregation, potentially contributing to Alzheimer's disease pathology.

Incidences of Helicobacter infection in pigs and tracing occupational hazard in pig farmers

The paper assesses Helicobacter prevalence in pigs and pig farmers, finding 19.63% of pig stomach samples and 2.08% of farmer stool samples positive for H. suis, with 3.12% positive for H. pylori.

Designer grass pea for transgene-free minimal neurotoxin-containing seeds with CRISPR-Cas9

This study uses CRISPR-Cas9 to create grass pea plants with minimal neurotoxin {beta}-ODAP in seeds, achieving 99% reduction without transgenes.

High-throughput quantitative screening of glucose-stimulated insulin secretion and insulin content using automated MAL-DI-TOF mass spectrometry

This study develops an automated MALDI-TOF mass spectrometry method for high-throughput screening of glucose-stimulated insulin secretion and insulin content in a 384-well plate format using Min6 cells.

An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis

The paper characterizes immune cell lipidomes and shows how lipid composition influences susceptibility to ferroptosis.

Glutathione-mediated S-Nitrosylation of WRKY75 modulates PHT1;5 expression to orchestrate phosphate homeostasis in Arabidopsis

The paper shows that glutathione-mediated S-nitrosylation of WRKY75 activates AtPHT1;5 to regulate phosphate homeostasis in Arabidopsis under phosphate starvation.

RNA molecules display distinctive organization at nuclear speckles

The paper uses super-resolution imaging to show that different RNA sequence domains localize to distinct regions within nuclear speckles, driven by RNA-protein interactions.

Biochemical identification of a nuclear coactivator protein required for AtrR-dependent gene regulation in Aspergillus fumigatus

This paper identifies NcaA, a nuclear coactivator protein required for AtrR-dependent gene regulation in Aspergillus fumigatus, showing its role in azole resistance.

Glycyrrhizin, an inhibitor of HMGB1 induces autolysosomal degradation function and inhibits H. pylori infection

This study shows glycyrrhizin, an HMGB1 inhibitor, restores lysosomal function and reduces H. pylori infection in gastric cells and mice.

Molecular mechanism of GTP binding- anddimerization-induced enhancement ofSar1-mediated membrane remodeling

This study uses molecular dynamics simulations to show that GTP binding enhances Sar1's membrane curvature generation by enabling full insertion of its amphipathic helix, while GDP-bound Sar1 only partially inserts, and dimerization further amplifies curvature.

Gut microbiota modulation in response to combination of Escherichia coli Nissle 1917 and sugars: Lessons from comparative analysis of fecal microbiota of two healthy donors from 2019-2021

The study examines how Escherichia coli Nissle 1917 combined with different sugars affects gut microbiota in two donors over 1.5 years, showing variations in microbial composition based on prebiotics and initial community structure.

A pandemic clonal lineage of the wheat blast fungus

The paper identifies a pandemic clonal lineage of the wheat blast fungus that originated in South America and spread to Asia and Africa, showing it can be controlled by Rmg8 but may develop fungicide resistance and recombine with African lineages.