SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate
M. J. Roy, S. Winkler, S. J. Hughes, C. Whitworth, M. Galant, W. Farnaby, K. Rumpel, A. Ciulli
This paper develops an SPR-based assay to measure PROTAC ternary complex dissociation kinetics and shows that differences in off-rates correlate with target degradation efficiency.
bioRxiv · Feb 3, 2019Biochemistry