Author

M. J. Roy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Hou· 2 shared O. Patel· 2 shared R. J. Daly· 2 shared X. Ma· 2 shared A. Ciulli· 1 shared A. Kropp· 1 shared B. C. Lechenberg· 1 shared C. Whitworth· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

J. Hou

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Author profile →

3 papers

Recent·Most cited

When two is a crowd - Structural mapping of PEAK pseudokinase interactions identifies 14 3 3 as a molecular switch for PEAK3/Crk signaling.

M. J. Roy, M. G. Surudoi, A. Kropp, J. Hou, W. Dai, J. M. Hardy, L.-Y. Liang, T. R. Cotton, B. C. Lechenberg, T. A. Dite, X. Ma, R. J. Daly, O. Patel, I. Lucet

The paper identifies 14-3-3 as a molecular switch for PEAK3/Crk signaling by mapping PEAK pseudokinase interactions and demonstrating a conserved high affinity 14-3-3 motif.

bioRxiv · Sep 1, 2022 · PreprintBiochemistry

PEAK3 pseudokinase represents a pro-migratory and -invasive signalling scaffold

J. Hou, E. V. Nguyen, M. Surudoi, M. J. Roy, O. Patel, I. S. Lucet, X. Ma, R. J. Daly

This study identifies PEAK3 as a pseudokinase that promotes cell migration and invasion through scaffolding interactions and tyrosine phosphorylation.

bioRxiv · Feb 17, 2021 · PreprintCancer Biology

SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate

M. J. Roy, S. Winkler, S. J. Hughes, C. Whitworth, M. Galant, W. Farnaby, K. Rumpel, A. Ciulli

This paper develops an SPR-based assay to measure PROTAC ternary complex dissociation kinetics and shows that differences in off-rates correlate with target degradation efficiency.

bioRxiv · Feb 3, 2019Biochemistry