Author

S. J. Hughes

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Ciulli· 1 shared C. Whitworth· 1 shared K. Rumpel· 1 shared M. Galant· 1 shared M. J. Roy· 1 shared S. Winkler· 1 shared W. Farnaby· 1 shared

Activity by Year

2019-2019 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Ciulli

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1 paper

Recent·Most cited

BiochemistrybioRxivFeb 3, 2019

SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate

M. J. Roy, S. Winkler, S. J. Hughes…·A. Ciulli

This paper develops an SPR-based assay to measure PROTAC ternary complex dissociation kinetics and shows that differences in off-rates correlate with target degradation efficiency.

DOI 10.1021/acschembio.9b00092

experimental assaydrug response / drug discovery

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