T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes
M. Darguzyte, P. Amtczak, D. Bachurski, P. Hoelker, N. Abedpour, R. Gholaminpoorfard, H. Schlösser, K. Wennhold, M. Thelen, M. Garcia-Marquez, J. Koenig, A. Schneider, T. Braun, F. Klawonn, M. Damrat, , R. Stripecke
This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.
bioRxiv · Mar 26, 2024 · PreprintImmunology