T. Braun

T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes

This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.

CXCL8 secreted by immature granulocytes inhibits wildtype hematopoiesis in chronic myelomonocytic leukemia

The paper identifies CXCL8 secreted by immature granulocytes as a factor inhibiting wildtype hematopoiesis in CMML, suggesting CXCL8 blockade could slow disease progression.

Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

The paper examines how parity affects the relationship between pre-pregnancy BMI, gestational weight gain, and gut microbiota changes during pregnancy and in infants.

Extracellular vesicles induce aggressive lung cancervia non-canonical integrin-EGFR-KRAS signaling

This study identifies a non-canonical ITGB2 signaling pathway that activates EGFR and RAS/MAPK/ERK in SCLC, leading to aggressive tumor behavior and resistance to EGFR inhibitors.

Ageing impairs the neuro-vascular interface in the heart

This study shows aging reduces nerve density in the left ventricle and dysregulates neuro-regulatory genes, leading to reduced heart rate variability.

Inhibiting Runx1 protects heart function after myocardial infarction

This study shows that inhibiting RUNX1 improves heart function after myocardial infarction by preserving contractility and mitochondrial function.

Fetal gut colonization: meconium does not have a detectable microbiota before birth

This study investigates whether fetal meconium contains detectable microbiota before birth and finds no microbial signal distinct from controls, suggesting colonization occurs after birth.

Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition

Notch1 inhibition restores alveolar epithelial differentiation, reduces surface tension, and reverses matrix deposition in lung fibrosis.

Microfluidic protein isolation and sample preparation for high resolution cryo-EM

This paper introduces a microfluidic method for isolating and preparing proteins for cryo-EM, enabling high-resolution structure determination from minimal cell lysate.