Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy
V. Joers, B. C. Murray, C. McLaughlin, D. Oliver, H. Staley, J. E. Coronado, C. Achat-Mendes, S. Golshani, S. D. Kelly, M. Goodson, D. Lee, F. P. Manfredsson, B. M. Moore, M. G. Tansey
This study shows that targeting CB2 with SMM-189 reduces alpha-synuclein aggregates and neuroinflammation in a rat model of Parkinson's disease.
bioRxiv · Aug 25, 2023Immunology