Molecular and cellular phenotypic differences distinguish murine syngeneic models from human tumors
W. Zhong, J. S. Myers, F. Wang, K. Wang, J. Lucas, E. Rosfjord, J. Lucas, A. T. Hooper, S. Yang, L. Lemon, M. Guffroy, C. May, J. R. Bienkowska, P. A. Rejto
This study identifies molecular and cellular differences between murine syngeneic tumor models and human tumors, highlighting limitations in using syngeneic models for immunotherapy research.
bioRxiv · Jul 5, 2019 · PreprintCancer Biology