J. Lucas

LC3-associated phagocytosis is impaired in monocyte-derived macrophages from systemic sclerosis patients

The ALOG domain defines a new family of plant-specific transcription factors acting during Arabidopsis flower development

This paper identifies the DNA binding motif and structural basis of the ALOG transcription factor family in Arabidopsis, revealing its role in organ boundary formation during flower development.

SEPALLATA-driven MADS transcription factor tetramerization is required for inner whorl floral organ development

The paper shows that SEPALLATA-driven MADS tetramerization is essential for inner whorl floral organ identity, beyond its role in meristem determinacy.

Plant-TFClass: a structural classification for plant transcription factors

The paper classifies plant transcription factors into a structural hierarchy based on DNA-binding domain structures, adding new classes and families not present in mammals.

Flavor Classification/Categorization and Differential Toxicity of Oral Nicotine Pouches (ONPs) in Lung Epithelial Cells

This study evaluates the toxicological effects of flavored oral nicotine pouches on lung epithelial cells, finding increased cytotoxicity, ROS production, and cytokine release.

The F-box cofactor UFO redirects the LEAFY floral regulator to novel cis-elements

This study identifies a novel mechanism by which the F-box protein UFO modulates the DNA-binding specificity of the master transcription factor LFY through direct interaction with novel cis-elements.

Reconstruction of hundreds of reference ancestral genomes across the eukaryotic kingdom

This paper reconstructs 624 ancestral genomes across eukaryotic kingdoms, providing high-resolution insights into genome and karyotype evolution across multiple clades.

The Intervening Domain Is Required For DNA-binding and Functional Identity of Plant MADS Transcription Factors

This study shows the Intervening domain is essential for DNA-binding and functional identity of plant MADS transcription factors through structural and functional analyses.

The making of cauliflowers: the story of unsuccessful flowers

The paper investigates how cauliflowers and Romanesco develop through hysteresis in floral networks and mutations affecting meristem growth.

The LEAFY floral regulator displays pioneer transcription factor properties

This study shows that LEAFY, a floral regulator in Arabidopsis, binds both methylated and non-methylated DNA and can induce chromatin accessibility in target genes.

Faster Cryptococcus melanization increases virulence in experimental and human cryptococcosis

This study shows that faster melanization in Cryptococcus species correlates with increased virulence and worse patient outcomes.

Pulmonary toxicity and inflammatory response of e-cigarettes containing medium-chain triglyceride oil and vitamin E acetate: Implications in the pathogenesis of EVALI but independent of SARS-COV-2 COVID-19 related proteins

This study investigates the pulmonary toxicity and inflammatory response of e-cigarettes containing MCT and VEA, showing they induce acute lung injury without involving SARS-CoV-2 proteins.

Effect of 10 UV filters on the brine shrimp Artemia salina and the marine microalgae Tetraselmis sp.

This study evaluates the toxicity of 10 UV filters on marine organisms, finding HS and OC most toxic, with HS effects reported at environmentally relevant concentrations.

Molecular and cellular phenotypic differences distinguish murine syngeneic models from human tumors

This study identifies molecular and cellular differences between murine syngeneic tumor models and human tumors, highlighting limitations in using syngeneic models for immunotherapy research.

Capturing auxin response factors syntax using DNA binding models

The paper models ARF DNA binding specificity using PWMs and identifies ARFbs syntax in auxin-regulated genes.