K. Wang

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila

The paper shows that lipid metabolism in Drosophila hepatocyte-like cells supports intestinal tumor growth through the TORC1-Hnf4 pathway, with potential therapeutic implications for cancer-associated metabolic dysfunction.

Characterization of the Gut Microbiota and Serum Metabolomics in Patients with Type 2 Diabetes Mellitus and Newly Diagnosed Acute Coronary Syndrome

This study identifies key gut microbiota and serum metabolite biomarkers that distinguish T2DM patients with ACS from those without, achieving high diagnostic accuracy using a multi-omics approach.

Decidual natural killer cells promote extravillous trophoblast developmental pathways: evidence from trophoblast organoid co-cultures

The paper shows that decidual natural killer cells promote trophoblast differentiation towards extravillous trophoblasts through MMP secretion and collagen remodeling in co-culture experiments.

Super-Enhancer Driven ZFP36L1 Promotes PD-L1 Expression in Infiltrative Gastric Cancer

This study identifies ZFP36L1, driven by a super-enhancer, as a key regulator of PD-L1 expression in infiltrative gastric cancer, contributing to immune escape.

ClpP-dependent protein quality control supports antibiotic persistence in Campylobacter jejuni through bioenergetic homeostasis

This study identifies ClpP-dependent proteostasis as critical for antibiotic persistence in C. jejuni through bioenergetic homeostasis and metabolic remodeling.

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

De novo synthesis of fatty acids in Archaea via an archaeal fatty acid synthase complex

This study shows that archaea can synthesize fatty acids using a newly identified pathway and enzyme complex, providing insights into their evolutionary lipid composition.

Phosphorylation-Dependent Activation of the bHLH Transcription Factor ICE1/SCRM Promotes Polarization of the Arabidopsis Zygote

This study shows that phosphorylation of the bHLH transcription factor SCRM by MPK3/6 promotes zygote polarization in Arabidopsis, contrasting with its role in epidermal cell divisions.

Cmai: Predicting Antigen-Antibody Interactions from Massive Sequencing Data

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

P-cadherin mechanoactivates tumor- mesothelium metabolic coupling to promote ovarian cancer metastasis

This study shows that P-cadherin-mediated mechanical forces on mesothelial cells enhance lipid production in ovarian cancer cells, promoting metastasis through lactate-driven lipogenesis.

Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment

This study identifies ETV2's role in endothelial cell specification by recruiting REST to repress alternative lineage genes through single-cell RNA-seq and ATAC-seq analyses.

A regulatory gene network that couples floral transition to shoot apical meristem morphology in Arabidopsis

The paper shows reciprocal repression between AP2 and SOC1 transcription factors couples floral transition to changes in shoot apical meristem morphology in Arabidopsis.

Mitochondrial Oxidative Phosphorylation Capacity in Skeletal Muscle Measured by Ultrafast Z-Spectroscopy (UFZ) MRI at 3T

This study evaluates ultrafast Z-spectroscopy MRI with pH correction for measuring mitochondrial oxidative phosphorylation in human skeletal muscle.

mRNA localization and thylakoid protein biogenesis in the filamentous heterocyst-forming cyanobacterium Anabaena sp. PCC 7120

The paper investigates mRNA localization and thylakoid protein biogenesis in Anabaena sp. PCC 7120, identifying an RNA-binding protein crucial for thylakoid protein translation and assembly.

ROS Mediated the Photodynamic Antibacterial of Vibrio vulnificus by a DNA-Targeted Molecular Rotor Probe

This paper introduces a novel fluorescent probe, BDTP, that effectively kills Vibrio vulnificus through photodynamic antibacterial activity and promotes wound healing in an animal model.

Protein disulfide isomerase disassembles stress granules and blocks cytoplasmic aggregation of TDP-43 in ALS

This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.

Single-nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root

This study uses single-nucleus multiomic and spatial transcriptomic data to identify gene regulatory dynamics and key regulators in human aortic root tissue under healthy and Marfan syndrome conditions.

Hosts Manipulate Lifestyle Switch and Pathogenicity Heterogeneity of Opportunistic Pathogens in the Single-cell Resolution

The paper shows how Drosophila larvae influence the lifestyle and pathogenicity of Serratia marcescens at the single-cell level through transcriptomic and metabolic changes.

SARS-CoV-2 serosurvey of healthy, privately owned cats presenting to a New York City animal hospital in the early phase of the COVID-19 pandemic (2020-2021)

This study reports a serosurvey of cats in New York City during the early pandemic, finding 16% seropositive for SARS-CoV-2 with higher prevalence in fall 2020 and evidence of human-cat transmission.

Unveiling Tryptophan Dynamics and Functions Across Model Organisms via Quantitative Imaging

This study uses GRIT to measure tryptophan dynamics across species and scales, revealing links between tryptophan metabolism, inflammation, and behavior.

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

This study develops rod-shaped Janus base nanopieces for improved tissue penetration and therapeutics delivery, showing better efficacy than spherical lipid nanoparticles in ovarian cancer models.

Self-inspired learning to denoise for live-cell super-resolution microscopy

This paper introduces SN2N, a self-supervised denoising method for live-cell super-resolution microscopy that achieves competitive performance without requiring large clean datasets.

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

This study identifies RBM7 deficiency as a driver of breast cancer metastasis through MFGE8 splicing regulation and NF-kB pathway suppression.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

An Endogenous Aryl Hydrocarbon Receptor Ligand Induces Preeclampsia-like Phenotypes: Transcriptome, Phosphoproteome, and Cell Functions

This study shows that an endogenous AhR ligand induces PE-like phenotypes by altering transcriptome, phosphoproteome, and vascular functions in pregnant rats and HUVECs.

Xanthomonas euvesicatoria effector XeAvrRxo1 triggers a Rxo1-mediated defense response in Nicotiana benthamiana and its chaperone Xe4429 functions as an antitoxin, an expression repressor, and an enhancer of XeAvrRxo1 secretion

This study identifies XeAvrRxo1 as a virulence and avirulence effector in X. euvesicatoria and shows that its chaperone Xe4429 suppresses toxicity, represses expression, and enhances secretion of XeAvrRxo1.

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

Field performance of the cardenolide-producing crucifer Erysimum cheiranthoides under herbivore attack and heterospecific competition.

This study examines how Erysimum cheiranthoides performs under herbivore attack and competition, finding that it escapes herbivory but suffers from competitive disadvantage.

Bni5 tethers myosin-II to septins to enhance retrograde actin flow and the robustness of cytokinesis

This study identifies Bni5's role in tethering myosin-II to septins in budding yeast, enhancing retrograde actin flow and cytokinesis robustness.