Author

M. H. J. Cordes

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Evolutionary Biology· 1

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Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Approach:statistical model· 1

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B. A. Wilson· 1 shared J. Bertram· 1 shared J. Masel· 1 shared S. G. Foy· 1 shared

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2018-2018 · peak 1/yr

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1 shared paperEvolutionary Biology

B. A. Wilson

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Evolutionary BiologybioRxivOct 23, 2018

A shift in aggregation avoidance strategy marks a long-term direction to protein evolution

S. G. Foy, B. A. Wilson, J. Bertram…·J. Masel

The paper shows that older genes have more interspersed hydrophobic residues compared to younger genes, indicating a long-term evolutionary trend toward reducing aggregation risk.

DOI 10.1534/genetics.118.301719

protein sequencestatistical model

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