Pirfenidone attenuates lung fibrotic fibroblast-mediated fibrotic responses to transforming growth factor-β1
J. Jin, S. Togo, K. Kadoya, m. tulafu, Y. Namba, M. Moe Iwai, J. Watanabe, K. Nagahama, T. Okabe, M. Hidayat, Y. Kodama, H. Kitamura, T. Ogura, N. Kitamura, K. Ikeo, , K. Takahashi
This study shows pirfenidone reduces fibrotic responses in lung fibroblasts by inhibiting CTHRC1, suggesting it as a potential therapeutic target for lung fibrosis.
bioRxiv · Aug 27, 2018Cell Biology