J. Jin

Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis

This study identifies FLRT2 as a critical regulator of venous-mediated angiogenesis and blood-brain barrier formation in the developing mouse CNS.

Molecular tension authenticates apoptotic cells being phagocytosed

The paper identifies molecular tension between phosphatidylserine and its receptors as a signal determining phagocytosis of apoptotic cells.

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

Inactivation of PRMT1 inhibits cardiac fibrosis via transcriptional regulation and perturbation of FBL activity in fibroblast-to-myofibroblast transition

This study shows that inhibiting PRMT1 reduces cardiac fibrosis by blocking fibroblast-to-myofibroblast transition through transcriptional regulation and disruption of FBL activity.

Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors

This study identifies WSB2 as a regulator of mitochondrial apoptosis and shows that targeting the WSB2-NOXA axis enhances sensitivity to BCL-2 inhibitors in cancer cells.

A step-emulsion based digital-RPA for Pathogenic bacteria detection

This paper develops a step-emulsion microfluidic device combined with digital-RPA for rapid, sensitive, and quantitative detection of Vibrio parahaemolyticus with a detection limit of 10 CFU/L.

3D live imaging and phenotyping of the subcellular cytotoxicity in cancer immunotherapy using event-triggered Bessel oblique plane microscopy

This study uses EBOPM to analyze subcellular events in CAR-T cells during immunotherapy, identifying key parameters correlated with cytotoxic function.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

Discovery of the First-in-class G9a/GLP PROTAC Degrader

This paper discovers a first-in-class PROTAC degrader for G9a/GLP, showing effective degradation and superior anticancer activity compared to existing inhibitors.

Evaluation of phantom doping materials in quantitative susceptibility mapping

This study evaluates four phantom doping materials for quantitative susceptibility mapping (QSM) by measuring molar susceptibility and test-retest repeatability at 3T and 7T.

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

Deep-Learning-Enabled Differentiation between Intraprostatic Gold Fiducial Markers and Calcification in Quantitative Susceptibility Mapping

This paper develops a deep learning model using QSM to differentiate gold fiducial markers from calcification in prostate cancer patients, achieving higher accuracy than conventional MRI methods.

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

This paper introduces a computational pipeline for identifying SARS-CoV-2 nsp14 inhibitors using virtual screening, identifying seven candidates including NSC620333 and SS148, with experimental validation of binding affinity and structural insights.

Pigmentation level of human iPSC-derived retinal pigment epithelium cell does not indicate a specific gene expression profile

The paper analyzes the relationship between pigmentation level and gene expression in human iPSC-derived RPE cells, finding no specific gene expression profile correlates with color intensity.

Microsporidia Ser/Thr Protein Phosphatase PP1 Targets DCs MAPK Pathway and Impairs Immune Functions

This study shows that Microsporidia infection impairs dendritic cell functions by targeting the p38/MAPK pathway via PP1, increasing susceptibility to secondary infections.

Assessment of bovine cortical bone fracture behavior using impact microindentation as a surrogate of fracture toughness

This study compares notched fracture toughness and impact microindentation in bovine bone to assess their correlation and potential as a non-destructive surrogate for fracture toughness.

KaScape: A sequencing-based method for global characterization of protein-DNA binding affinity

KaScape quantitatively characterizes TF-DNA binding affinity across all possible sequences using next-generation sequencing and provides a tool to visualize the affinity landscape.

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

The paper uses CRISPR screens in iPSC-derived neurons to identify factors controlling tau aggregation, finding new pathways and potential therapeutic targets for tauopathies.

Ebola Virus Sequesters IRF3 in Viral Inclusion Bodies to Evade Host Antiviral Immunity

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

How is Emotional Evidence from Multiple Sources Used in Perceptual Decision Making?

This study examines how humans sample and integrate multiple emotional stimuli during deliberate decision-making, finding that extreme emotional evidence is sampled more but weighted equally.

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy

This paper introduces MS147, a novel degrader of PRC1 components BMI1 and RING1B, which selectively degrades these proteins and inhibits cancer cell proliferation.

A stable reference human transcriptome and proteome as a standard for reproducible omics experiments

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

Phase-dependent gait robustness is not related to phase-dependent gait stability

The paper shows that phase-dependent stability measures in a compass walker model do not predict gait robustness or fall risk.

The energetic effect of hip flexion and retraction in walking at different speeds: a modeling study

This study models how hip flexion and retraction affect energy cost in walking at different speeds, finding that asymmetric hip actuation reduces metabolic cost of transport by up to 6% at medium speeds.

A cryptic transactivation domain of EZH2 binds AR and AR's splice variant promoting oncogene activation and tumorous transformation

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

Prevalent regulation of GATA2/3 and MSX2 on endogenous retrovirus-derived regulatory elements in human trophoblast stem cells

This study identifies GATA2/3 and MSX2 as key regulators of ERV-derived enhancers in human trophoblast stem cells, revealing their role in placental gene regulation.

A Microfluidic Chip for LAMP-based Multiplex Detection of Pathogen

The paper develops a microfluidic chip for LAMP-based multiplex detection of three bacterial pathogens and reports LOD values for Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

Molecular Architecture of the Chikungunya Virus Replication Complex

This study determines the structure of the chikungunya virus replication complex at near-atomic and subnanometer resolution, revealing its molecular architecture and implications for antiviral therapy.

WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.