K. Takahashi

The paper identifies novel subgroups in myeloid malignancies using a network-based clustering approach that integrates genomic and clinical features, improving prognostic accuracy.

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

This study examines protist community dynamics during termite adult eclosion and dispersal, finding that changes in community composition enhance transmission efficiency.

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

The paper identifies three endosymbiotic Clostridia in termite gut protists, revealing they are energy parasites with genome features suggesting obligate intracellular parasitism.

This study quantifies the motility differences between sperm packets and asexual colonies of Pleodorina starrii, revealing distinct flagellar waveform patterns and motility characteristics.

This study shows that diet-induced obesity disrupts chromatin oxygen sensing in macrophages, impairing hypoxia-induced glycolysis and efferocytosis.

This study identifies MCL1 as a survival factor in RAS-mutated CMML, explaining resistance to BCL2 inhibitors and suggesting new therapeutic targets.

This study constructs a FliF-FliG fusion protein that enables MS-ring formation in E. coli, revealing its role in flagellar motor assembly and force generation.

This study shows clomipramine inhibits GTPase activity of dynamin 2 and 3, similar to dynamin 1, suggesting it may block SARS-CoV-2 entry.

This study identifies MpHYPNOS as a key regulator of gemma dormancy in liverworts, showing it represses cell cycle genes and induces ABA biosynthesis through an ABA-independent pathway.

The study identifies a domestic cat hepadnavirus infection in a Japanese cat, showing genetic differences from global strains.

The paper examines the morphology and phylogeny of Karenia selliformis and other co-occurred dinoflagellates in a harmful algal bloom in eastern Hokkaido, Japan, identifying morphological variation and genetic similarity to a bloom in Kamchatka, Russia.

This paper introduces a stress-reduced passaging technique for human pluripotent stem cells that improves viability and downstream application efficiency without altering cell characteristics.

This study tracks 26-year aboveground biomass changes in a Japanese old-growth forest, finding steady increases driven by compensating growth and climate factors.

This paper introduces a statistical test, GeneAccord, to identify clonally exclusive gene pairs in tumours and applies it to AML data, finding 6 exclusive and 2 co-occurring pairs.

This study uses meta-analysis of DNA microarray data to identify gravity-sensitive genes, finding that SLCO2A1 expression decreases under microgravity.

The paper shows that cholesterol and sphingomyelin are required for TBK1-mediated phosphorylation of STING at the TGN, mirroring in vivo conditions.

This study examines fungal co-occurrence networks along an elevation gradient on Mt. Norikura, finding that climate factors dominate network connectivity patterns, with significant declines between 700 m and 1500 m elevation.

This study shows that ESRG, a HERV-H-driven lncRNA in human pluripotent stem cells, is not required for maintaining or reprogramming pluripotency.

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

This study shows the SARS-CoV-2 D614G variant replicates more efficiently and transmits faster in hamsters than the wildtype virus.

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

This study examines clinicopathologic features and treatment outcomes in 65 patients with atypical chronic myeloid leukemia, identifying key mutations and predictors of survival.

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

This study shows IL-19 reduces experimental autoimmune encephalomyelitis by inhibiting macrophage activation and Th17 cell expansion, suggesting potential therapeutic use in multiple sclerosis.

This study shows red sea bream juveniles can learn to avoid angling gear after minimal exposure, retaining memory of the gear two months later.

The paper develops an improved auxin-inducible degron system with an engineered auxin-TIR1 pair that reduces auxin concentration requirements and enables efficient protein depletion in human and mouse cells.

This study develops a single-cell genomic sequencing technique to identify bacterial responders to dietary fiber in the mouse gut microbiota, revealing metabolic pathways and functional lineages involved in fiber fermentation.