Moderate and intensive mechanical loading differentially modulate the phenotype of tendon stem/progenitor cells in vivo
J. Zhang, D. Nie, K. Williamson, A. McDowell, M. Hogan, J. H.-C. Wang
This study shows that moderate treadmill running maintains tendon homeostasis by promoting TSC differentiation into tenocytes, while intensive treadmill running induces tendinopathy by causing TSCs to differentiate into non-tenocyte cells.
bioRxiv · Nov 9, 2020Cell Biology