Characterization of resistance to a potent D-peptide HIV entry inhibitor
A. R. Smith, M. T. Weinstock, A. E. Siglin, F. G. Whitby, J. N. Francis, C. P. Hill, D. M. Eckert, M. J. Root, M. S. Kay
This study identifies mutations conferring resistance to the D-peptide HIV inhibitor PIE12-trimer and shows they reduce inhibitor affinity but also impair viral fitness.
bioRxiv · Aug 28, 2019Microbiology