C. P. Hill

This study visualizes the Cdc48 AAA+ ATPase unfolding pathway using structural snapshots, revealing a hand-over-hand mechanism and the sequential ATP hydrolysis and substrate interaction between D1 and D2 subunits.

This study investigates the function of two cytochrome c homologs in the mitochondrial electron transport chain of malaria parasites, revealing that one is essential while the other has unique structural properties and is not required for blood-stage growth.

This study shows that CAPN7 interacts with IST1 at midbodies to regulate abscission and the NoCut checkpoint through proteolytic activity.

The paper identifies somatostatin venom analogs from fish-hunting cone snails, showing their potential as therapeutic leads for pain, cancer, and endocrine disorders.

The paper develops the MIDAS platform to identify protein-metabolite interactions, revealing novel regulatory mechanisms in carbohydrate metabolism.

This study shows UCH37 deubiquitinates branched ubiquitin chains, enhancing proteasome clearance of stress-induced inclusions.

This study identifies mutations conferring resistance to the D-peptide HIV inhibitor PIE12-trimer and shows they reduce inhibitor affinity but also impair viral fitness.

This study identifies Vms1p as the tRNA hydrolase that releases nascent polypeptides in the RQC pathway for degradation.