Cancer BiologybioRxivPreprint
Taxane chemotherapy leads to breast cancer dormancy escape by stromal injury mediated IL-6/MAP2K signaling
R. Ganesan, S. S. Bhasin, U. Krishnan…·V. P. Sukhatme
This study shows that taxane chemotherapy induces stromal injury, releasing IL-6 and G-CSF that promote cancer dormancy escape via MEK/ERK signaling, and suggests targeting these cytokines or pathways to prevent recurrence.
DOI 10.1101/2022.07.10.499472