Author

M. L. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:mechanistic / dynamical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

G. Fiorin· 2 shared A. Yazici· 1 shared C. M. MacDermaid· 1 shared C. MacDermaid· 1 shared D. Granata· 1 shared H. Liu· 1 shared K. W. Hall· 1 shared M. A. Kasimova· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

G. Fiorin

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Author profile →

3 papers

Recent·Most cited

The SPICA Coarse-Grained Force Field for Proteins and Peptides

S. Kawamoto, H. Liu, S. Seo, Y. Miyazaki, M. Dixit, R. DeVane, C. MacDermaid, G. Fiorin, M. L. Klein, W. Shinoda

The paper develops and improves a coarse-grained force field for proteins and peptides, showing good performance in simulating membrane protein behavior and interactions.

bioRxiv · Dec 1, 2021 · PreprintBiophysics

Coexistence of lipid phases stabilizes interstitial water in the outer layer of mammalian skin

C. M. MacDermaid, K. W. Hall, R. H. DeVane, M. L. Klein, G. Fiorin

This study uses molecular dynamics simulations to show that lipid phase coexistence in the stratum corneum creates water droplets that facilitate hydrophilic permeation.

bioRxiv · Oct 11, 2019Biophysics

TRPV1 activation relies on hydration/dehydration of nonpolar cavities

M. A. Kasimova, A. Yazici, Y. Yudin, D. Granata, M. L. Klein, T. Rohacs, V. Carnevale

The paper investigates TRPV1 gating mechanisms using simulations and electrophysiology, finding that hydration of nonpolar cavities is critical for channel opening and temperature sensitivity.

bioRxiv · May 5, 2017Biophysics