M. L. Siegal

Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects

This study measures the fitness effects of spontaneous single-nucleotide substitutions and microsatellite mutations in yeast, finding they have distinct distributions of mutational effects on growth rate.

Deep sequencing of natural and experimental populations of Drosophila melanogaster reveals biases in the spectrum of new mutations

The paper analyzes mutation rates and patterns in Drosophila melanogaster using mutation accumulation lines and rare polymorphisms, revealing biases in the mutation spectrum and its evolutionary implications.