S. Tilk

Cancers adapt to their mutational load by buffering protein misfolding stress

The paper shows high mutational load tumors upregulate proteostasis machinery to buffer protein misfolding stress, revealing therapeutic vulnerabilities.

Direct observation of adaptive tracking on ecological timescales in Drosophila

The paper tracks phenotypic and genomic adaptation in Drosophila over ten generations, showing rapid and dynamic responses to environmental change.

Most cancers carry a substantial deleterious load due to Hill-Robertson interference

This study shows that most cancers do not remove deleterious mutations due to Hill-Robertson interference, leading to a 40% average fitness cost per cell.

Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

The paper identifies parallel seasonal allele frequency shifts in Drosophila melanogaster across North America and Europe, linking environmental conditions to genomic responses to selection.

Accurate allele frequencies from ultra-low coverage pool-seq samples in evolve-and-resequence experiments

This paper introduces a method to accurately estimate allele frequencies from low-coverage pool-seq data in evolve-and-resequence experiments using haplotype inference.

Deep sequencing of natural and experimental populations of Drosophila melanogaster reveals biases in the spectrum of new mutations

The paper analyzes mutation rates and patterns in Drosophila melanogaster using mutation accumulation lines and rare polymorphisms, revealing biases in the mutation spectrum and its evolutionary implications.