J. Park

Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma

This study identifies genomic heterogeneity and ploidy as markers of intrinsic resistance to PD-1 blockade in metastatic melanoma, with a decision tree model predicting resistance with high confidence.

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

3D printed bioelectronic scaffolds with soft tissue-like stiffness

This study develops 3D printed PEDOT:PSS hydrogel scaffolds with soft tissue-like stiffness to support cell viability and function in bioelectronic applications.

The N-degron pathway governs autophagy to promote thermotolerance in Arabidopsis

The paper shows that ATG8a turnover via the Arg/N-degron pathway regulates autophagy and thermotolerance in Arabidopsis during heat stress.

Intercellular adhesion boots collective cell migration through elevated membrane tension

This study shows that intercellular adhesion can drive collective cell migration through membrane tension and phospholipase D2 signaling, independent of cytoskeletal coupling.

An Autonomous Implantable Device for the Prevention of Death from Opioid Overdose

The paper introduces an implantable device that autonomously detects and treats opioid overdose, improving survival rates by delivering naloxone and alerting first responders.

Differential cell-ECM interaction of rhabdomyosarcoma subtypes regulated by PAX3-FOXO1

This study identifies differences in cell-ECM interaction between rhabdomyosarcoma subtypes, showing FNRMS has heightened interaction regulated by TGFβ signaling, while PAX3-FOXO1 in FPRMS suppresses this interaction.

Molecular tension authenticates apoptotic cells being phagocytosed

The paper identifies molecular tension between phosphatidylserine and its receptors as a signal determining phagocytosis of apoptotic cells.

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

This study shows that zebrafish gut microbiome influences protein absorption by altering lysosome-rich enterocytes' expression of digestion machinery and microbial interactions.

Participatory science methods to monitor water quality and ground truth remote sensing of the Chesapeake Bay

The paper describes participatory science methods for monitoring water quality in the Chesapeake Bay using volunteer scientists and remote sensing to improve data collection and algorithm development.

Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5

This study shows that JAK inhibition increases uSTAT5 levels, which promotes HSC maintenance and stemness, and reveals a new role for uSTAT5 in controlling HSC function.

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

This paper develops SIRPα-expressing extracellular vesicles from engineered stem cells to treat acute liver failure by resolving necroptosis and promoting liver regeneration, showing reduced liver damage and improved survival in models.

Digital Profiling of Tumor Extracellular Vesicle-associated RNAs Directly from Unprocessed Blood Plasma

EV-CLIP detects tumor-derived extracellular vesicle RNAs directly from blood plasma with high sensitivity, enabling precise monitoring of cancer mutations and EV subpopulations.

Cholesterol Metabolite 27-Hydroxycholesterol Enhances the Secretion of Cancer Promoting Extracellular Vesicles by a Mitochondrial ROS-Induced Impairment of Lysosomal Function

This study shows that 27-hydroxycholesterol increases EV secretion by impairing lysosomal function through mitochondrial ROS, and antioxidant treatment reverses this effect.

The molecular framework underlying the growth and defense tradeoff in Arabidopsis roots in response to danger signals

This study investigates how PEP1 danger signals affect root meristem development in Arabidopsis by analyzing gene expression changes and identifying STZ as a key regulator of growth-defense tradeoffs.

A framework for quality control in quantitative proteomics

The paper introduces a framework for quality control in quantitative proteomics, combining internal and external QC measures with tools for data analysis and deposition.

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

This study shows DKK2 is required for colon cancer metastasis by generating cancer cells with Paneth cell properties through HNF4A regulation.

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

Mutability and hypermutation antagonize immunoglobulin codon optimality

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

High-throughput single-cell, single-mitochondrial DNA assay using hydrogel droplet microfluidics

This paper introduces a high-throughput method for single-cell, single-mtDNA analysis using agarose-based droplet microfluidics, achieving high mtDNA retention and enabling scalable analysis.

Plant-associated fungi co-opt ancient antimicrobials for host manipulation

The paper identifies antimicrobial effectors in plant-associated fungi, suggesting they evolved from ancient antimicrobials to manipulate host microbiota and immunity.

Exploring the impact of microbial manipulation on the early development of kelp (Saccharina latissima) using an ecological core microbiome framework.

This study identifies core bacterial taxa associated with wild kelp and tests their impact on cultivated kelp growth, finding a positive correlation between bacterial frequency and developmental effect.

Newly Sequenced Genomes Reveal Patterns of Gene Family Expansion in select Dragonflies (Odonata: Anisoptera)

This study identifies gene family expansions in two dragonfly families, linking them to ecological and life history traits, and finds Odonata has lower gene turnover than other insects.

Revealing 3D cancer tissue structures using holotomography and virtual hematoxylin and eosin staining via deep learning

This paper develops a 3D virtual H&E staining method using holotomography and deep learning for cancer tissues, validated on colon and gastric cancer samples.

Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in response to a chronic hypertensive environment

This study shows that chronic hypertension remodels stimulus-secretion coupling in rat adrenal medulla, reducing catecholamine secretion to protect against excessive blood pressure.

Somatic structural variants driving distinct modes of oncogenesis in melanoma

This study analyzes structural variants in melanoma subtypes, identifying distinct genomic properties and molecular drivers that may inform therapeutic strategies.

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

This study identifies RBM39 as a regulator of innate immunity by controlling transcription and splicing of key interferon response factors, revealing its potential as a therapeutic target.