The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation to allow viral replication and myocardial injury
Y. Guo, M. M. Hinchman, M. Lewandrowski, S. T. Cross, D. M. Sutherland, O. L. Welsh, T. S. Dermody, J. S. L. Parker
This study identifies σ3 as a reovirus virulence factor that suppresses PKR activation and stress granule formation, linking these functions to viral replication and myocardial injury in mice.
bioRxiv · Mar 22, 2021Microbiology