Author

M. Lipsitch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 6 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 8 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Fraser· 3 shared J. Corander· 3 shared W. P. Hanage· 3 shared B. J. Arnold· 2 shared C. Colijn· 2 shared N. J. Croucher· 2 shared T. Azarian· 2 shared W. Hanage· 2 shared

Activity by Year

2017-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersEvolutionary Biology

C. Fraser

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures

G. L. Harrow, J. A. Lees, W. P. Hanage, M. Lipsitch, J. Corander, C. Colijn, N. J. Croucher

The paper tests whether negative frequency-dependent selection and asymmetrical recombination can explain the stability of multi-strain bacterial populations using simulations and genomic data.

bioRxiv · Jun 5, 2020Evolutionary Biology

Predicting evolution using frequency-dependent selection in bacterial populations

T. Azarian, P. P. P. Martinez, B. J. Arnold, L. R. Grant, J. Corander, C. Fraser, N. Croucher, L. Hammitt, R. Reed, M. Santosham, R. R. Weatherholtz, S. D. Bentley, K. L. O'Brien, M. Lipsitch, W. P. Hanage

The paper predicts changes in pneumococcal populations after vaccination by analyzing accessory gene frequencies under negative frequency-dependent selection.

bioRxiv · Feb 25, 2020 · PreprintEvolutionary Biology

Quantifying the surveillance required to sustain genetic marker-based antibiotic resistance diagnostics

A. L. Hicks, S. M. Kissler, M. Lipsitch, Y. H. Grad

The paper quantifies the surveillance needed to maintain the effectiveness of genetic marker-based antibiotic resistance diagnostics by identifying sampling and testing rates for early detection of novel resistance variants.

bioRxiv · Jul 11, 2019 · PreprintMicrobiology

On the evolutionary ecology of multidrug resistance in bacteria

S. Lehtinen, F. Blanquart, M. Lipsitch, C. Fraser, The Maela Pneumococcal Collaboration

This paper explains high multidrug resistance frequencies in bacteria through ecological models of strain competition, showing that resistance to different antibiotics often co-occurs due to stable coexistence rather than competitive exclusion.

bioRxiv · Jan 10, 2019Evolutionary Biology

Population genomics of pneumococcal carriage in Massachusetts children following PCV-13 introduction

P. Mitchell, T. Azarian, N. J. Croucher, A. Callendrello, C. M. Thompson, S. I. Pelton, M. Lipsitch, W. Hanage

This study examines changes in pneumococcal carriage diversity and lineage distribution in Massachusetts children after PCV-13 introduction, finding increased diversity post-vaccination followed by a return to pre-vaccination levels.

bioRxiv · Dec 16, 2017Evolutionary Biology

Host population structure and treatment frequency maintain balancing selection on drug resistance

S. Cobey, E. B. Baskerville, C. Colijn, W. Hanage, C. Fraser, M. Lipsitch

The paper models how host population structure and treatment frequency influence the coexistence of drug-sensitive and resistant strains of Streptococcus pneumoniae.

bioRxiv · Jul 16, 2017Evolutionary Biology

Weak epistasis may drive adaptation in recombining bacteria

B. J. Arnold, M. Gutmann, Y. Grad, S. K. Sheppard, J. Corander, M. Lipsitch, W. P. Hanage

This study shows that weak epistasis can influence adaptation in recombining bacteria, even when recombination is frequent, due to limited transfer of genetic segments.

bioRxiv · Mar 23, 2017Evolutionary Biology

Exploring The Role Of Competition Induced By Non-Vaccine Serotypes For Herd Protection

G. Masala, M. Lipsitch, C. Bottomley, S. Flasche

This study investigates how increasing vaccine valency affects indirect protection against pneumococcal carriage, finding that higher valency may reduce vaccine impact unless efficacy against carriage is improved.

bioRxiv · Mar 21, 2017Ecology