Author

B. J. Arnold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Assay:whole-genome sequencing· 4 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

J. Corander· 3 shared W. P. Hanage· 3 shared M. Lipsitch· 2 shared Y. Grad· 2 shared B. J. Raphael· 1 shared C. B. Wadsworth· 1 shared C. Fraser· 1 shared C. Wadsworth· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersEvolutionary Biology

J. Corander

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Author profile →

6 papers

Recent·Most cited

HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing data

M. A. Myers, B. J. Arnold, V. Bansal, K. M. Mullen, S. Zaccaria, B. J. Raphael

HATCHet2 improves copy number inference from bulk tumor sequencing by identifying clone- and haplotype-specific aberrations, revealing new mirrored-subclonal CNAs in prostate cancer.

bioRxiv · Jul 13, 2023Cancer Biology

Predicting evolution using frequency-dependent selection in bacterial populations

T. Azarian, P. P. P. Martinez, B. J. Arnold, L. R. Grant, J. Corander, C. Fraser, N. Croucher, L. Hammitt, R. Reed, M. Santosham, R. R. Weatherholtz, S. D. Bentley, K. L. O'Brien, M. Lipsitch, W. P. Hanage

The paper predicts changes in pneumococcal populations after vaccination by analyzing accessory gene frequencies under negative frequency-dependent selection.

bioRxiv · Feb 25, 2020 · PreprintEvolutionary Biology

Fine-scale haplotype structure reveals strong signatures of positive selection in a recombining bacterial pathogen

B. J. Arnold, M. Sohail, C. Wadsworth, J. Corander, W. P. Hanage, S. Sunyaev, Y. Grad

The paper identifies strong signatures of positive selection in Neisseria gonorrhoeae by analyzing fine-scale haplotype structure and linkage patterns between nonsynonymous alleles.

bioRxiv · May 10, 2019Evolutionary Biology

An introduced crop plant is driving diversification of the virulent bacterial pathogen Erwinia tracheiphila

L. R. Shapiro, J. N. Paulson, B. J. Arnold, E. D. Scully, O. Zhaxybayeva, N. Pierce, J. Rocha, V. Klepac-Ceraj, K. Holton, R. Kolter

The paper sequenced E. tracheiphila genomes to show introduced cucumber plants drive its diversification into distinct lineages.

bioRxiv · Jun 12, 2018Evolutionary Biology

Azithromycin resistance through interspecific acquisition of an epistasis dependent efflux pump component and transcriptional regulator in Neisseria gonorrhoeae

C. B. Wadsworth, B. J. Arnold, M. R. Sater, Y. H. Grad

The paper identifies epistatic interactions between mtrD and promoter mutations in Neisseria gonorrhoeae that contribute to azithromycin resistance through horizontal gene transfer.

bioRxiv · Apr 27, 2018Microbiology

Weak epistasis may drive adaptation in recombining bacteria

B. J. Arnold, M. Gutmann, Y. Grad, S. K. Sheppard, J. Corander, M. Lipsitch, W. P. Hanage

This study shows that weak epistasis can influence adaptation in recombining bacteria, even when recombination is frequent, due to limited transfer of genetic segments.

bioRxiv · Mar 23, 2017Evolutionary Biology