Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia
M. Ferrer, N. Mourikis, E. E. Davidson, S. O. Kleeman, M. Zaccaria, J. Habel, R. Rubino, T. R. Flint, C. M. Connell, M. Lukey, E. P. White, A. P. Coll, A. R. Venkitaraman, T. Janowitz
This study shows that a ketogenic diet slows tumor growth but accelerates cachexia and shortens survival in IL-6-driven cancer models by inducing ferroptosis and corticosterone deficiency.
bioRxiv · Feb 17, 2023Cancer Biology