Author

T. Janowitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

A. R. Venkitaraman· 2 shared E. P. White· 2 shared M. Ferrer· 2 shared Y. Gao· 2 shared Z. Wang· 2 shared A. Kucukural· 1 shared A. L. Queiroz· 1 shared A. Murthy· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

A. R. Venkitaraman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer.

H. T. Langer, S. Ramsamooj, E. Dantas, A. Murthy, M. Ahmed, S.-K. Hwang, R. Grover, R. Pozovskiy, R. J. Liang, A. L. Queiroz, J. C. Brown, E. P. White, T. Janowitz, M. D. Goncalves

This study shows that rosiglitazone restores adiponectin levels and preserves tissue mass in mice with lung cancer by enhancing AMPK and AKT activity.

bioRxiv · Jul 31, 2023Cancer Biology

Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia

M. Ferrer, N. Mourikis, E. E. Davidson, S. O. Kleeman, M. Zaccaria, J. Habel, R. Rubino, T. R. Flint, C. M. Connell, M. Lukey, E. P. White, A. P. Coll, A. R. Venkitaraman, T. Janowitz

This study shows that a ketogenic diet slows tumor growth but accelerates cachexia and shortens survival in IL-6-driven cancer models by inducing ferroptosis and corticosterone deficiency.

bioRxiv · Feb 17, 2023Cancer Biology

CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer

H. Mou, J. Yue, Y. Jin, Z. Wang, Y. Gao, T. Janowitz, H. V. Meyer, A. Kucukural, J. E. Wilkinson, D. M. Ozata, S. Beyaz

This study shows CRISPR/Cas9 can induce exon skipping in β-catenin, creating gain-of-function mutations that drive distinct liver cancer subtypes in mice and are found in human HCC patients.

bioRxiv · Mar 27, 2022Cancer Biology

Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia

M. Petruzzelli, M. Ferrer, M. Schuijs, Z. Hall, D. Perera, S. Raghunathan, M. Vacca, E. Gaude, M. J. Lukey, D. I. Jodrell, C. Frezza, E. F. Wagner, T. Janowitz, T. Y. F. Halim, A. R. Venkitaraman

The paper shows that early neutrophilia driven by aerobic glycolysis supports host metabolism and delays cancer cachexia in murine models.

bioRxiv · Aug 11, 2021Cancer Biology

Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy

Z. Wang, R. Yan, J. Li, Y. Gao, P. Moresco, M. Yao, J. F. Hechtman, M. J. Weiss, T. Janowitz, D. T. Fearon

The paper shows pancreatic cancer cells use transglutaminase-2 to create CXCL12-keratin 19 coatings that block T cells and resist immunotherapy.

bioRxiv · Sep 4, 2020 · PreprintImmunology

Stromal Amyloid β drives Neutrophil extracellular trap formation to augment tumour growth

H. Munir, J. O. Jones, T. Janowitz, C. P. Martins, S. P. Welsh, J. D. Shields

This paper identifies CAF-derived Amyloid β as a driver of tumor-induced NETosis, which promotes tumor growth and poor prognosis in human cancers.

bioRxiv · Jan 10, 2020 · PreprintCancer Biology