TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction
H. Khan, H. Winstone, J. Jimenez-Guardeno, C. Graham, K. Doores, C. Goujon, D. Matthews, A. Davidson, S. Rihn, M. Palmarini, S. Neil, M. Malim
This study shows that NCOA7 restricts SARS-CoV-2 infection by promoting endosomal acidification, and TMPRSS2 or removal of the furin cleavage site reduces this restriction.
bioRxiv · Jul 23, 2021Microbiology