C. Graham

Fes-deficient macrophages enhance CD8+ T cell priming and tumour control through increased proinflammatory cytokine production and localization

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

Broad and potent neutralizing mAbs are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection

The paper shows that vaccinated individuals develop broad neutralizing mAbs after Delta/BA.1 infection, but these mAbs are less effective against newer variants.

Biophysical characterisation of the structure of a SARS-CoV-2 self-amplifying - RNA (saRNA) vaccine

This paper characterizes the biophysical properties of a SARS-CoV-2 self-amplifying RNA vaccine using multiple analytical techniques.

Future climate change-related decreases in food quality may affect juvenile Chinook salmon growth and survival

This study shows that low-quality diets with reduced essential fatty acids negatively impact juvenile Chinook salmon growth, condition, and survival, highlighting the importance of food quality under climate change.

Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes

This study uses cfChIP-seq on plasma samples to subtype SCLC based on epigenetic states, linking plasma nucleosome data to tumor transcriptomes and developing a classifier for lineage-defining transcription factors.

Modular capsid decoration boosts adenovirus vaccine-induced humoral and cellular immunity against SARS-CoV-2

This paper describes a method to enhance adenovirus vaccine efficacy by decorating capsid surfaces with antigens, resulting in improved humoral immunity and retained T cell responses.

Partial sex linkage and linkage disequilibrium on the guppy sex chromosome

The paper analyzes PoolSeq data from guppy populations to assess sex linkage and recombination suppression, finding evidence of linkage disequilibrium but no consistent male-specific variants.

The interaction of climate history and evolution impacts alpine biodiversity assembly differently in freshwater and on land

The paper examines how climate history and evolution shaped alpine biodiversity differently in freshwater and terrestrial ecosystems, finding distinct patterns of speciation linked to glacial refugia and adaptive radiation.

ChAdOx1 nCoV-19 (AZD1222) vaccine elicits monoclonal antibodies with potent cross-neutralizing activity against SARS-CoV-2 viral variants

This study isolates monoclonal antibodies from a vaccinated individual and shows they neutralize multiple SARS-CoV-2 variants effectively.

ROS signalling requires uninterrupted electron flow and is lost during ageing in flies

The paper shows that ROS-RET signalling requires uninterrupted electron flow through the ETC and is lost during ageing in flies, leading to persistent mtROS production and reduced stress adaptation.

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

This study shows that NCOA7 restricts SARS-CoV-2 infection by promoting endosomal acidification, and TMPRSS2 or removal of the furin cleavage site reduces this restriction.

Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors

This paper develops a mouse model of PanNETs driven by Cdk5 and shows its relevance to human tumors, supporting Cdk5 as a therapeutic target.

ADNKA overcomes SARS-CoV2-mediated NK cell inhibition through non-spike antibodies

This study identifies ADNKA as a mechanism by which SARS-CoV-2-infected cells evade NK cell inhibition, showing that non-spike antibodies drive sustained NK activation and cytokine production.

Evidence for microbiome-dependent chilling tolerance in Sorghum

This study investigates how soil microbiomes affect sorghum's chilling tolerance, finding that microbial inoculation can enhance shoot biomass and leaf area under chilling stress in some genotypes.

Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

This study examines how mutations in the B.1.1.7 variant of SARS-CoV-2 affect neutralization by monoclonal antibodies targeting non-RBD epitopes.

The impact of Spike mutations on SARS-CoV-2 neutralization

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

Evaluating Specimen Quality and Results from a Community-Wide, Home-Based Respiratory Surveillance Study

The paper evaluates the quality of specimens and results from a home-based respiratory surveillance study to assess its feasibility for community-level monitoring of respiratory pathogens.

The clinical and molecular significance associated with STING signaling in estrogen receptor-positive early breast cancer

The paper identifies perinuclear STING (pnSTING) in ER+ breast cancer as a prognostic marker linked to immune infiltration and poor outcomes in low pnSTING tumors.

Using GC content to compare recombination patterns on the sex chromosomes and autosomes of the guppy, Poecilia reticulata, and its close outgroup species

The paper uses GC content to infer recombination patterns in guppy chromosomes, finding high recombination rates near chromosome ends and no evidence of distinct XY recombination patterns.