Bradycardic mice undergo effective heart rate improvement after specific homing to the sino-atrial node and differentiation of adult muscle derived stem cells.
P. Mesirca, D. Mamaeva, I. Bidaud, M. Baudot, R. Davaze, M. L. DiFrancesco, V. Mitutsova, A. G. Torrente, N. Arsic, J. Nargeot, J. Striessnig, A. Lee, N. Lamb, M. Mangoni, A. Fernandez
This study shows that adult muscle-derived stem cells can differentiate into cardiac pacemaker cells and improve heart rate in bradycardic mice.
bioRxiv · Apr 7, 2020 · PreprintCell Biology