Author

P. Mesirca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:electrophysiology· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. E. Mangoni· 3 shared A. Fernandez· 2 shared A. G. Torrente· 2 shared M. L. DiFrancesco· 2 shared N. Lamb· 2 shared R. Davaze· 2 shared A. Bucchi· 1 shared A. Hivonnait· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPhysiology

M. E. Mangoni

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Optical control of cardiac rhythm by in vivo photoactivation of an ERG channel peptide inhibitor

J. Montnach, H. Millet, A. Persello, H. Meudal, S. De Waard, P. Mesirca, B. Ribeiro, J. Richard, A. Hivonnait, A. Tessier, B. Lauzier, F. Charpentier, M. E. Mangoni, C. Landon, C. jopling, M. De Waard

This study uses photopharmacology to control cardiac rhythm in vivo by uncaging a peptide inhibitor of the ERG channel, showing spatially restricted effects on heart rate and conduction.

bioRxiv · Mar 23, 2023 · PreprintPharmacology & Toxicology

Mouse lemur, a new animal model to investigate cardiac pacemaker activity in primates.

M. L. DiFrancesco, R. Davaze, E. Torre, P. Mesirca, M. Marrot, C. Lautier, P. Fontes, J. Cuoq, A. Fernandez, N. Lamb, F. Pifferi, N. Mestre Frances, M. E. Mangoni, A. G. Torrente

This study characterizes cardiac pacemaker activity in mouse lemurs, revealing similarities to human SAN function and potential for modeling age-related cardiovascular dysfunctions.

bioRxiv · Oct 25, 2021 · PreprintPhysiology

Bradycardic mice undergo effective heart rate improvement after specific homing to the sino-atrial node and differentiation of adult muscle derived stem cells.

P. Mesirca, D. Mamaeva, I. Bidaud, M. Baudot, R. Davaze, M. L. DiFrancesco, V. Mitutsova, A. G. Torrente, N. Arsic, J. Nargeot, J. Striessnig, A. Lee, N. Lamb, M. Mangoni, A. Fernandez

This study shows that adult muscle-derived stem cells can differentiate into cardiac pacemaker cells and improve heart rate in bradycardic mice.

bioRxiv · Apr 7, 2020 · PreprintCell Biology

Structure-guided design of a cell penetrating peptide preventing cAMP modulation of HCN channels

A. Moroni, A. Saponaro, F. Cantini, A. Porro, A. Bucchi, D. DiFrancesco, V. Maione, C. Donadoni, B. Introini, P. Mesirca, M. E. Mangoni, G. Thiel, L. Banci, B. Santoro

The paper designs a cell-penetrating peptide, TRIPnano, that blocks cAMP modulation of HCN channels by competing for binding and inducing allosteric changes, reducing spontaneous action potential firing in sinoatrial node myocytes by 30%.

bioRxiv · Jan 24, 2018Physiology