Conformational clamping by a membrane ligand activates the EphA2 receptor
J. M. Westerfield, A. Sahoo, D. S. Alves, B. Grau, A. Cameron, M. Maxwell, J. Schuster, P. C. T. Souza, I. Mingarro, M. Buck, F. N. Barrera
The paper identifies a peptide that activates EphA2 by binding to its transmembrane domain, revealing a mechanism where the peptide acts as a molecular clamp to stabilize the active conformation of the receptor.
bioRxiv · Apr 8, 2021Biophysics