BiophysicsbioRxiv
Conformational clamping by a membrane ligand activates the EphA2 receptor
J. M. Westerfield, A. Sahoo, D. S. Alves…·F. N. Barrera
The paper identifies a peptide that activates EphA2 by binding to its transmembrane domain, revealing a mechanism where the peptide acts as a molecular clamp to stabilize the active conformation of the receptor.
DOI 10.1016/j.jmb.2021.167144