A. Sahoo

Martini without the twist: Unveiling a mechanically correct microtubule through bottom-up coarse-graining in Martini 3

The paper develops a coarse-grained microtubule model using Martini 3 and elastic networks to accurately simulate mechanical properties at a larger scale than atomistic simulations.

diaPASEF Enables High-throughput Proteomic Analysis of Host Cell Proteins for Biopharmaceutical Process Development

The paper evaluates diaPASEF for HCP analysis in biopharmaceutical processes, showing improved quantification and throughput compared to standard methods.

Unraveling the Molecular Complexity of N-TerminusHuntingtin Oligomers: Insights into Polymorphic Structures

This study uses molecular dynamics simulations to investigate how varying polyglutamine lengths affect the structural diversity of Huntingtin oligomers, revealing their role in Huntington's disease pathogenesis.

Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

The paper uses molecular dynamics simulations to show how sequence context and polyQ tract length affect temperature-dependent condensate formation in ELF3-PrD, influencing plant growth responses.

Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

Conformational clamping by a membrane ligand activates the EphA2 receptor

The paper identifies a peptide that activates EphA2 by binding to its transmembrane domain, revealing a mechanism where the peptide acts as a molecular clamp to stabilize the active conformation of the receptor.

Modified Vaccinia Ankara Based SARS-CoV-2 Vaccine Expressing Full-Length Spike Induces Strong Neutralizing Antibody Response

This study develops two MVA-based SARS-CoV-2 vaccines, MVA/S and MVA/S1, and finds that MVA/S induces stronger neutralizing antibodies against SARS-CoV-2 compared to MVA/S1.

Exosome-mediated MIR211 modulates tumor microenvironment via the DUSP6-ERK5 axis and contributes to BRAFV600E inhibitor resistance in melanoma.

This study shows MIR211 promotes melanoma growth and resistance to BRAF inhibitors by modulating the DUSP6-ERK5 axis via exosome transfer in the tumor microenvironment.