Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges
A. Geng, R. G. Brenig, J. Roux, M. Luetge, H.-W. Cheng, E. E. Flint, M.-A. Meier, O. T. Pop, P. Kuenzler-Heule, M. McPhail, S. Soysal, D. Semela, M. Heim, C. J. Weston, B. Ludewig, C. Bernsmeier
The paper identifies CD52-expressing monocytes in cirrhosis that enhance innate immunity, but their loss during acute decompensation correlates with infection and poor outcomes.
bioRxiv · Apr 3, 2024 · PreprintImmunology